| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM86428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595424 (CHEMBL1040065) |
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| Ki | 0.75±n/a nM |
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| Citation |  de la Fuente, T; Martín-Fontecha, M; Sallander, J; Benhamú, B; Campillo, M; Medina, RA; Pellissier, LP; Claeysen, S; Dumuis, A; Pardo, L; López-Rodríguez, ML Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. J Med Chem53:1357-69 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_MOUSE | Htr6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47012.98 |
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| Organism: | MOUSE |
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| Description: | 5-HT6 HTR6 MOUSE::Q9R1C8 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQC
RLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQ
VPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCIS
PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHS
GARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNF
FVTDSVEPEIRQHPLGSPMN
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| BDBM86428 |
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| n/a |
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| Name | BDBM86428 |
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| Synonyms: | SB-258585 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22IN3O3S |
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| Mol. Mass. | 487.355 |
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| SMILES | COc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1N1CCN(C)CC1 |
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| Structure | 
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