| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Procathepsin L |
|---|
| Ligand | BDBM50304288 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_605778 (CHEMBL1074596) |
|---|
| Ki | 2100±n/a nM |
|---|
| Citation |  Micale, N; Ettari, R; Schirmeister, T; Evers, A; Gelhaus, C; Leippe, M; Zappalà, M; Grasso, S Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem17:6505-11 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Procathepsin L |
|---|
| Name: | Procathepsin L |
|---|
| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37557.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Purchased from Calbiochem (San Diego, CA). |
|---|
| Residue: | 333 |
|---|
| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
|---|
| BDBM50304288 |
|---|
| n/a |
|---|
| Name | BDBM50304288 |
|---|
| Synonyms: | 2-(4-Acetylphenylureido)-1-(4-methoxyphenyl)-6,7-methylenedioxy-2H-isoquinolin-3-one | CHEMBL594623 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H21N3O6 |
|---|
| Mol. Mass. | 471.4614 |
|---|
| SMILES | COc1ccc(cc1)-c1n(NC(=O)Nc2ccc(cc2)C(C)=O)c(=O)cc2cc3OCOc3cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
