Reaction Details |
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Target | Trifunctional purine biosynthetic protein adenosine-3 |
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Ligand | BDBM50249877 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_610926 (CHEMBL1067649) |
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IC50 | 5510000±n/a nM |
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Citation | Wang, L; Cherian, C; Desmoulin, SK; Polin, L; Deng, Y; Wu, J; Hou, Z; White, K; Kushner, J; Matherly, LH; Gangjee, A Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. J Med Chem53:1306-18 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Trifunctional purine biosynthetic protein adenosine-3 |
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Name: | Trifunctional purine biosynthetic protein adenosine-3 |
Synonyms: | GAR transformylase | Gart | PUR2_MOUSE |
Type: | PROTEIN |
Mol. Mass.: | 107504.27 |
Organism: | Mus musculus |
Description: | ChEMBL_497843 |
Residue: | 1010 |
Sequence: | MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQ
FCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIP
TAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSF
GAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAP
QVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEA
QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKD
IGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLP
QLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTR
IYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEG
ELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN
LIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLV
ISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
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BDBM50249877 |
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n/a |
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Name | BDBM50249877 |
Synonyms: | (S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid | CHEMBL491104 | N-{4-[4-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)-butyl]benzoyl}-L-glutamic Acid |
Type | Small organic molecule |
Emp. Form. | C22H24N4O6S |
Mol. Mass. | 472.514 |
SMILES | Nc1nc2sc(CCCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| |
Structure |
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