Reaction Details |
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Target | Proton-coupled folate transporter |
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Ligand | BDBM18796 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_610924 (CHEMBL1067647) |
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pH | 5.5±n/a |
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Ki | 96±n/a nM |
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Comments | extracted |
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Citation | Wang, L; Cherian, C; Desmoulin, SK; Polin, L; Deng, Y; Wu, J; Hou, Z; White, K; Kushner, J; Matherly, LH; Gangjee, A Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. J Med Chem53:1306-18 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proton-coupled folate transporter |
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Name: | Proton-coupled folate transporter |
Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 49782.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469597 |
Residue: | 459 |
Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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BDBM18796 |
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n/a |
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Name | BDBM18796 |
Synonyms: | (2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid | LY231514 | Pemetrexed |
Type | Small organic molecule |
Emp. Form. | C20H21N5O6 |
Mol. Mass. | 427.4106 |
SMILES | Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r| |
Structure |
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