| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50306874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_608664 (CHEMBL1067150) |
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| IC50 | 1420±n/a nM |
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| Citation |  Hegde, VR; Borges, S; Pu, H; Patel, M; Gullo, VP; Wu, B; Kirschmeier, P; Williams, MJ; Madison, V; Fischmann, T; Chan, TM Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. Bioorg Med Chem Lett20:1384-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50306874 |
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| n/a |
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| Name | BDBM50306874 |
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| Synonyms: | 8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[1,2,3-cd]indol-5-one | CHEMBL609040 | SCH-535270 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9NO4 |
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| Mol. Mass. | 279.247 |
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| SMILES | Oc1cccc2c1cc1NC(=O)c3cc4OCOc4c2c13 |
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| Structure | 
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