Reaction Details |
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Target | Heparanase |
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Ligand | BDBM50307400 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_610684 (CHEMBL1072345) |
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Kd | 350±n/a nM |
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Citation | Johnstone, KD; Karoli, T; Liu, L; Dredge, K; Copeman, E; Li, CP; Davis, K; Hammond, E; Bytheway, I; Kostewicz, E; Chiu, FC; Shackleford, DM; Charman, SA; Charman, WN; Harenberg, J; Gonda, TJ; Ferro, V Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth. J Med Chem53:1686-99 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heparanase |
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Name: | Heparanase |
Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
Type: | PROTEIN |
Mol. Mass.: | 61167.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327900 |
Residue: | 543 |
Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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BDBM50307400 |
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n/a |
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Name | BDBM50307400 |
Synonyms: | CHEMBL604366 | hexadecasodium [3-({4-[(4-{[3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]-4-{[3,4,5-tris(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-2-yl)oxy]-3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-2-yl}oxy)-2-(octyloxy)-5-(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-4-yl] sulfate |
Type | Small organic molecule |
Emp. Form. | C38H52O74S16 |
Mol. Mass. | 2205.824 |
SMILES | CCCCCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O |r| |
Structure |
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