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TargetHeparanase
LigandBDBM50307400
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610684 (CHEMBL1072345)
Kd 350±n/a nM
Citation Johnstone, KDKaroli, TLiu, LDredge, KCopeman, ELi, CPDavis, KHammond, EBytheway, IKostewicz, EChiu, FCShackleford, DMCharman, SACharman, WNHarenberg, JGonda, TJFerro, V Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth. J Med Chem53:1686-99 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heparanase
Name:Heparanase
Synonyms:Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:PROTEIN
Mol. Mass.:61167.67
Organism:Homo sapiens (Human)
Description:ChEMBL_327900
Residue:543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50307400
n/a
NameBDBM50307400
Synonyms:CHEMBL604366 | hexadecasodium [3-({4-[(4-{[3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]-4-{[3,4,5-tris(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-2-yl]oxy}oxan-2-yl]oxy}-3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-2-yl)oxy]-3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-2-yl}oxy)-2-(octyloxy)-5-(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-4-yl] sulfate
TypeSmall organic molecule
Emp. Form.C38H52O74S16
Mol. Mass.2205.824
SMILESCCCCCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O |r|
Structure
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