Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 2A

Ligand

BDBM50184800

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_608747 (CHEMBL1067760)

1750±n/a nM

Citation

Neves, G; Menegatti, R; Antonio, CB; Grazziottin, LR; Vieira, RO; Rates, SM; Noël, F; Barreiro, EJ; Fraga, CA Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorg Med Chem18:1925-35 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 2A

Name:

5-hydroxytryptamine receptor 2A

Synonyms:

5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52852.05

Organism:

Rattus norvegicus (rat)

Description:

Rat cortex membranes 5-HT2A receptors.

Residue:

471

Sequence:

MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

BDBM50184800

n/a

Name

BDBM50184800

Synonyms:

1-Phenyl-4-[(1-phenyl-1H-pyrazol-4-yl)methyl]piperazine | 1-phenyl-4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazine | CHEMBL210405

Type

Small organic molecule

Emp. Form.

C20H22N4

Mol. Mass.

318.4155

SMILES

C(N1CCN(CC1)c1ccccc1)c1cnn(c1)-c1ccccc1

Structure