| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50308012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_608747 (CHEMBL1067760) |
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| Ki | 3220±n/a nM |
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| Citation |  Neves, G; Menegatti, R; Antonio, CB; Grazziottin, LR; Vieira, RO; Rates, SM; Noël, F; Barreiro, EJ; Fraga, CA Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorg Med Chem18:1925-35 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52852.05 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat cortex membranes 5-HT2A receptors. |
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| Residue: | 471 |
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| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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| BDBM50308012 |
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| n/a |
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| Name | BDBM50308012 |
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| Synonyms: | 1-(4-Chlorophenyl)-4-{[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]methyl}piperazine | CHEMBL597411 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19Cl2N5 |
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| Mol. Mass. | 388.294 |
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| SMILES | Clc1ccc(cc1)N1CCN(Cc2cn(nn2)-c2ccc(Cl)cc2)CC1 |
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| Structure | 
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