| Reaction Details |
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 | Report a problem with these data |
| Target | Cystine/glutamate transporter |
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| Ligand | BDBM50378668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607279 (CHEMBL1072821) |
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| IC50 | 225000±n/a nM |
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| Citation |  Patel, SA; Rajale, T; O'Brien, E; Burkhart, DJ; Nelson, JK; Twamley, B; Blumenfeld, A; Szabon-Watola, MI; Gerdes, JM; Bridges, RJ; Natale, NR Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. Bioorg Med Chem18:202-13 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cystine/glutamate transporter |
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| Name: | Cystine/glutamate transporter |
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| Synonyms: | SLC7A11 | XCT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55437.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_772170 |
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| Residue: | 501 |
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| Sequence: | MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGA
GIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGP
LPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLN
SMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFY
YGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLS
NAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHV
RKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRP
FKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIM
SEKITRTLQIILEVVPEEDKL
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| BDBM50378668 |
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| n/a |
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| Name | BDBM50378668 |
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| Synonyms: | CHEMBL606915 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19N5O7 |
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| Mol. Mass. | 489.437 |
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| SMILES | CC(N=Nc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O)c1c(CCc2ccc3ccccc3c2)onc1C(O)=O |w:2.1| |
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| Structure | 
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