Reaction Details |
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Target | Cystine/glutamate transporter |
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Ligand | BDBM50378667 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_607278 (CHEMBL1072820) |
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Ki | 64000±n/a nM |
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Citation | Patel, SA; Rajale, T; O'Brien, E; Burkhart, DJ; Nelson, JK; Twamley, B; Blumenfeld, A; Szabon-Watola, MI; Gerdes, JM; Bridges, RJ; Natale, NR Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. Bioorg Med Chem18:202-13 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cystine/glutamate transporter |
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Name: | Cystine/glutamate transporter |
Synonyms: | SLC7A11 | XCT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 55437.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_772170 |
Residue: | 501 |
Sequence: | MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGA
GIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGP
LPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLN
SMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFY
YGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLS
NAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHV
RKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRP
FKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIM
SEKITRTLQIILEVVPEEDKL
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BDBM50378667 |
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n/a |
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Name | BDBM50378667 |
Synonyms: | CHEMBL604574 |
Type | Small organic molecule |
Emp. Form. | C15H11F6N3O3 |
Mol. Mass. | 395.2566 |
SMILES | CC(N=Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1c(C)onc1C(O)=O |w:2.1| |
Structure |
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