| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50309051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612940 (CHEMBL1070892) |
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| Ki | 158±n/a nM |
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| Citation |  Scott, JD; Li, SW; Wang, H; Xia, Y; Jayne, CL; Miller, MW; Duffy, RA; Boykow, GC; Kowalski, TJ; Spar, BD; Stamford, AW; Chackalamannil, S; Lachowicz, JE; Greenlee, WJ Diaryl piperidines as CB1 receptor antagonists. Bioorg Med Chem Lett20:1278-83 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50309051 |
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| n/a |
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| Name | BDBM50309051 |
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| Synonyms: | CHEMBL589169 | N-(((3R,6S)-1-(4-chlorophenyl)-6-(2,4-dichlorophenyl)piperidin-3-yl)methyl)cyclopropanesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23Cl3N2O2S |
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| Mol. Mass. | 473.844 |
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| SMILES | Clc1ccc(cc1)N1C[C@H](CNS(=O)(=O)C2CC2)CC[C@H]1c1ccc(Cl)cc1Cl |r| |
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| Structure | 
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