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TargetSynaptic vesicular amine transporter
LigandBDBM50080827
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610810 (CHEMBL1068127)
Ki 970±n/a nM
Citation Hojahmat, M; Horton, DB; Norrholm, SD; Miller, DK; Grinevich, VP; Deaciuc, AG; Dwoskin, LP; Crooks, PA Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorg Med Chem18:640-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Synaptic vesicular amine transporter
Name:Synaptic vesicular amine transporter
Synonyms:Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2
Type:PROTEIN
Mol. Mass.:55709.61
Organism:Homo sapiens (Human)
Description:ChEMBL_610810
Residue:514
Sequence:
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50080827
n/a
NameBDBM50080827
Synonyms:(2R,6S)-1-Methyl-2,6-diphenethyl-piperidine | (2S,6R)-1-Methyl-2,6-diphenethyl-piperidine | CHEMBL1085811 | CHEMBL333465 | Lobelane | cis-N-methyl-2,6-diphenethylpiperidine
TypeSmall organic molecule
Emp. Form.C22H29N
Mol. Mass.307.4724
SMILESCN1[C@@H](CCc2ccccc2)CCC[C@H]1CCc1ccccc1 |r|
Structure
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