Ki Summary

Reaction Details

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Target

HSP90 and hnRNPA2/B1

Ligand

BDBM20926

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_616152

0.064±n/a nM

Citation

Biamonte MA; Van de Water R; Arndt JW; Scannevin RH; Perret D; Lee WC Heat shock protein 90: inhibitors in clinical trials. J Med Chem 53:3-17 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

HSP90 and hnRNPA2/B1

Name:

HSP90 and hnRNPA2/B1

Synonyms:

HSP 84 | HSP 90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) | Heat shock protein HSP 90-beta

Type:

Molecular Chaperone

Mol. Mass.:

83229.45

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

724

Sequence:

MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD

BDBM20926

n/a

Name

BDBM20926

Synonyms:

5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide | Isoxazole, 40f | VER-52296/NVP-AUY922

Type

Small organic molecule

Emp. Form.

C26H31N3O5

Mol. Mass.

465.5414

SMILES

CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O

Structure