| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|
| Ligand | BDBM50312990 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_616133 (CHEMBL1102996) |
|---|
| Kd | 87±n/a nM |
|---|
| Citation |  Gong, L; Hirschfeld, D; Tan, YC; Heather Hogg, J; Peltz, G; Avnur, Z; Dunten, P Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett20:1693-6 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|
| Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 69222.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y463 |
|---|
| Residue: | 629 |
|---|
| Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
|
|
|
|---|
| BDBM50312990 |
|---|
| n/a |
|---|
| Name | BDBM50312990 |
|---|
| Synonyms: | (R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | CHEMBL1082152 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20FN3O4 |
|---|
| Mol. Mass. | 409.4103 |
|---|
| SMILES | Cn1cc(C2=C(C(=O)NC2=O)c2cccc(NCC(O)CO)c2)c2cc(F)ccc12 |t:4| |
|---|
| Structure | 
|
|---|
Search and Browse
