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TargetHistamine H4 receptor
LigandBDBM50315318
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625969 (CHEMBL1103488)
IC50 169±n/a nM
Citation Cramp, SDyke, HJHiggs, CClark, DEGill, MSavy, PJennings, NPrice, SLockey, PMNorman, DPorres, SWilson, FJones, ARamsden, NMangano, RLeggate, DAndersson, MHale, R Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett20:2516-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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  Blast E-value cutoff:
BDBM50315318
n/a
NameBDBM50315318
Synonyms:8-chloro-4-(5-methyl-2,5-diazabicyclo[2.2.2]octan-2-yl)benzofuro[3,2-d]pyrimidine | CHEMBL1092933
TypeSmall organic molecule
Emp. Form.C17H17ClN4O
Mol. Mass.328.796
SMILESCN1CC2CCC1CN2c1ncnc2c1oc1ccc(Cl)cc21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: