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TargetMelanocortin receptor 3 (MC3R)
LigandBDBM50315675
Substrate/Competitorn/a
Meas. Tech.ChEMBL_624017
EC50 71±n/a nM
Citation Lansdell MIHepworth DCalabrese ABrown ADBlagg JBurring DJWilson PFradet DBrown TBQuinton FMistry NTang KMount NStacey PEdmunds NAdams CGaboardi SNeal-Morgan SWayman CCole SPhipps JLewis MVerrier HGillon VFeeder NHeatherington ASultana SHaughie SMartin SWSudworth MTweedy S Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem 53:3183-97 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 3 (MC3R)
Name:Melanocortin receptor (M3 and M4)
Synonyms:MC3-R | MC3R | Melanocortin MC3 | Melanocortin receptor (M3 and M4) | Melanocortin receptor 3
Type:Enzyme
Mol. Mass.:36044.86
Organism:Homo sapiens (Human)
Description:P41968
Residue:323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315675
n/a
NameBDBM50315675
Synonyms:((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone | CHEMBL1089103
TypeSmall organic molecule
Emp. Form.C29H31F2N3O2
Mol. Mass.491.5721
SMILESC[C@H]1CN(C[C@@H](C)[C@]1(O)c1ccccc1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(F)cc1F)c1ccccn1 |r|
Structure
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