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TargetMelanocortin receptor 3
LigandBDBM50315685
Substrate/Competitorn/a
Meas. Tech.ChEMBL_624017 (CHEMBL1116903)
EC50>24700±n/a nM
Citation Lansdell, MIHepworth, DCalabrese, ABrown, ADBlagg, JBurring, DJWilson, PFradet, DBrown, TBQuinton, FMistry, NTang, KMount, NStacey, PEdmunds, NAdams, CGaboardi, SNeal-Morgan, SWayman, CCole, SPhipps, JLewis, MVerrier, HGillon, VFeeder, NHeatherington, ASultana, SHaughie, SMartin, SWSudworth, MTweedy, S Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem53:3183-97 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 3
Name:Melanocortin receptor 3
Synonyms:MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:Enzyme
Mol. Mass.:36044.86
Organism:Homo sapiens (Human)
Description:P41968
Residue:323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315685
n/a
NameBDBM50315685
Synonyms:((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-propylpiperidin-1-yl)methanone | CHEMBL1090161
TypeSmall organic molecule
Emp. Form.C25H38F2N2O2
Mol. Mass.436.5782
SMILESCCC[C@]1(O)[C@@H](C)CN(C[C@H]1C)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r|
Structure
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