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TargetMelanocortin receptor 4
LigandBDBM50378743
Substrate/Competitorn/a
Meas. Tech.ChEMBL_624023 (CHEMBL1116909)
Ki 36±n/a nM
Citation Lansdell, MIHepworth, DCalabrese, ABrown, ADBlagg, JBurring, DJWilson, PFradet, DBrown, TBQuinton, FMistry, NTang, KMount, NStacey, PEdmunds, NAdams, CGaboardi, SNeal-Morgan, SWayman, CCole, SPhipps, JLewis, MVerrier, HGillon, VFeeder, NHeatherington, ASultana, SHaughie, SMartin, SWSudworth, MTweedy, S Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem53:3183-97 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50378743
n/a
NameBDBM50378743
Synonyms:CHEMBL1204061
TypeSmall organic molecule
Emp. Form.C28H35F3N2O2
Mol. Mass.488.5849
SMILESC[C@H]1CN(C[C@@H](C)[C@]1(O)c1ccc(F)cc1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C |r|
Structure
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