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TargetMelanocyte-stimulating hormone receptor
LigandBDBM50378748
Substrate/Competitorn/a
Meas. Tech.ChEMBL_624018 (CHEMBL1116904)
EC50 3900±n/a nM
Citation Lansdell, MIHepworth, DCalabrese, ABrown, ADBlagg, JBurring, DJWilson, PFradet, DBrown, TBQuinton, FMistry, NTang, KMount, NStacey, PEdmunds, NAdams, CGaboardi, SNeal-Morgan, SWayman, CCole, SPhipps, JLewis, MVerrier, HGillon, VFeeder, NHeatherington, ASultana, SHaughie, SMartin, SWSudworth, MTweedy, S Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem53:3183-97 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocyte-stimulating hormone receptor
Name:Melanocyte-stimulating hormone receptor
Synonyms:MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:Enzyme
Mol. Mass.:34717.23
Organism:Homo sapiens (Human)
Description:Q01726
Residue:317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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BDBM50378748
n/a
NameBDBM50378748
Synonyms:CHEMBL1204054
TypeSmall organic molecule
Emp. Form.C25H32F2N4O2
Mol. Mass.458.544
SMILESCCC[C@]1(O)[C@@H](C)CN(C[C@H]1C)C(=O)[C@H]1CN(C[C@@H]1c1ccc(F)cc1F)c1cccnn1 |r|
Structure
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