| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM31093 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_630524 (CHEMBL1104796) |
|---|
| IC50 | 172±n/a nM |
|---|
| Citation |  Adams, ND; Adams, JL; Burgess, JL; Chaudhari, AM; Copeland, RA; Donatelli, CA; Drewry, DH; Fisher, KE; Hamajima, T; Hardwicke, MA; Huffman, WF; Koretke-Brown, KK; Lai, ZV; McDonald, OB; Nakamura, H; Newlander, KA; Oleykowski, CA; Parrish, CA; Patrick, DR; Plant, R; Sarpong, MA; Sasaki, K; Schmidt, SJ; Silva, DJ; Sutton, D; Tang, J; Thompson, CS; Tummino, PJ; Wang, JC; Xiang, H; Yang, J; Dhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem53:3973-4001 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM31093 |
|---|
| n/a |
|---|
| Name | BDBM31093 |
|---|
| Synonyms: | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | BDBM31832 | CHEMBL259084 | MLN-8054 | cid_11712649 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H15ClF2N4O2 |
|---|
| Mol. Mass. | 476.862 |
|---|
| SMILES | OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
