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TargetAurora kinase C
LigandBDBM50315769
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630525 (CHEMBL1104797)
IC50 6.5±n/a nM
Citation Adams, NDAdams, JLBurgess, JLChaudhari, AMCopeland, RADonatelli, CADrewry, DHFisher, KEHamajima, THardwicke, MAHuffman, WFKoretke-Brown, KKLai, ZVMcDonald, OBNakamura, HNewlander, KAOleykowski, CAParrish, CAPatrick, DRPlant, RSarpong, MASasaki, KSchmidt, SJSilva, DJSutton, DTang, JThompson, CSTummino, PJWang, JCXiang, HYang, JDhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem53:3973-4001 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase C
Name:Aurora kinase C
Synonyms:AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C
Type:Enzyme
Mol. Mass.:35602.43
Organism:Homo sapiens (Human)
Description:Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315769
n/a
NameBDBM50315769
Synonyms:3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea | 4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | CHEMBL1090479 | GSK-1070916
TypeSmall organic molecule
Emp. Form.C30H33N7O
Mol. Mass.507.6293
SMILESCCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN(C)C)c1
Structure
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