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TargetAurora kinase B
LigandBDBM50316474
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630516 (CHEMBL1104788)
IC50 2.1±n/a nM
Citation Adams, NDAdams, JLBurgess, JLChaudhari, AMCopeland, RADonatelli, CADrewry, DHFisher, KEHamajima, THardwicke, MAHuffman, WFKoretke-Brown, KKLai, ZVMcDonald, OBNakamura, HNewlander, KAOleykowski, CAParrish, CAPatrick, DRPlant, RSarpong, MASasaki, KSchmidt, SJSilva, DJSutton, DTang, JThompson, CSTummino, PJWang, JCXiang, HYang, JDhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem53:3973-4001 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50316474
n/a
NameBDBM50316474
Synonyms:4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | CHEMBL1095788
TypeSmall organic molecule
Emp. Form.C32H35N7O
Mol. Mass.533.6666
SMILESCCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN2CCCC2)c1
Structure
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