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TargetAurora kinase A
LigandBDBM50316488
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630519 (CHEMBL1104791)
IC50 2445±n/a nM
Citation Adams, NDAdams, JLBurgess, JLChaudhari, AMCopeland, RADonatelli, CADrewry, DHFisher, KEHamajima, THardwicke, MAHuffman, WFKoretke-Brown, KKLai, ZVMcDonald, OBNakamura, HNewlander, KAOleykowski, CAParrish, CAPatrick, DRPlant, RSarpong, MASasaki, KSchmidt, SJSilva, DJSutton, DTang, JThompson, CSTummino, PJWang, JCXiang, HYang, JDhanak, D Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem53:3973-4001 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50316488
n/a
NameBDBM50316488
Synonyms:CHEMBL1095988 | N-(4-{1-Ethyl-4-[2-({[2-(4-morpholinyl)ethyl]amino}methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N'-phenylurea
TypeSmall organic molecule
Emp. Form.C32H36N8O2
Mol. Mass.564.6806
SMILESCCn1cc(c(n1)-c1ccc(NC(=O)Nc2ccccc2)cc1)-c1ccnc2[nH]c(CNCCN3CCOCC3)cc12
Structure
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