| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl endopeptidase |
|---|
| Ligand | BDBM50051547 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_632259 (CHEMBL1110121) |
|---|
| IC50 | 29±n/a nM |
|---|
| Citation |  Lawandi, J; Gerber-Lemaire, S; Juillerat-Jeanneret, L; Moitessier, N Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem53:3423-38 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl endopeptidase |
|---|
| Name: | Prolyl endopeptidase |
|---|
| Synonyms: | 3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 80758.04 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | n/a |
|---|
| Residue: | 710 |
|---|
| Sequence: | MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP
|
|
|
|---|
| BDBM50051547 |
|---|
| n/a |
|---|
| Name | BDBM50051547 |
|---|
| Synonyms: | (S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | (S)-tert-butyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate | CHEMBL311364 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H24N2O3 |
|---|
| Mol. Mass. | 268.352 |
|---|
| SMILES | CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
