| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM50317401 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_631615 (CHEMBL1106609) |
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| IC50 | 229±n/a nM |
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| Citation |  Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Bioorg Med Chem18:3307-19 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35037.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22748 |
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| Residue: | 312 |
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| Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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| BDBM50317401 |
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| n/a |
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| Name | BDBM50317401 |
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| Synonyms: | 5-(Aminosulfonyl)-2-(phenylthio)-N-propylnicotinamide | CHEMBL1099125 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N3O3S2 |
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| Mol. Mass. | 351.444 |
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| SMILES | CCCNC(=O)c1cc(cnc1Sc1ccccc1)S(N)(=O)=O |
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| Structure | 
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