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TargetWD repeat-containing protein 5
LigandBDBM50318534
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633069 (CHEMBL1118769)
IC50 1±n/a nM
Citation Karatas, HTownsend, ECBernard, DDou, YWang, S Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. J Med Chem53:5179-85 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
WD repeat-containing protein 5
Name:WD repeat-containing protein 5
Synonyms:BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:Protein
Mol. Mass.:36597.13
Organism:Homo sapiens (Human)
Description:P61964
Residue:334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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  Blast E-value cutoff:
BDBM50318534
n/a
NameBDBM50318534
Synonyms:(7S,24S,27S,30S,33S,36S,39S,42S)-36-((1H-imidazol-5-yl)methyl)-27-(4-aminobutyl)-42-((2S,3R)-2-((S)-2-((S)-2-aminopropanamido)-5-guanidinopentanamido)-3-hydroxybutanamido)-7-carbamoyl-1-(2-carboxy-6-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl)-30-(3-guanidinopropyl)-24-(hydroxymethyl)-33-isobutyl-39-isopropyl-1,9,16,23,26,29,32,35,38,41-decaoxo-2,8,15,22,25,28,31,34,37,40-decaazapentatetracontan-45-oic acid | CHEMBL1082290
TypeSmall organic molecule
Emp. Form.C91H136N24O24
Mol. Mass.1950.1999
SMILESCC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCCCCCC(=O)NCCCCCC(=O)N[C@@H](CCCCNC(=O)c1c(cccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(O)=O)C(N)=O |r,wU:61.61,81.81,8.15,35.43,22.28,103.103,wD:52.54,46.47,31.32,72.72,18.19,4.4,(35.79,-14.77,;35.8,-13.23,;37.14,-12.47,;34.48,-12.45,;34.49,-10.91,;33.18,-10.12,;31.83,-10.87,;31.82,-12.41,;30.5,-10.09,;30.52,-8.55,;31.87,-7.79,;33.23,-8.43,;34.3,-7.3,;33.54,-5.95,;32.03,-6.26,;29.16,-10.85,;27.82,-10.08,;27.84,-8.54,;26.47,-10.84,;25.16,-10.03,;23.82,-10.79,;23.8,-12.33,;22.5,-10.02,;22.52,-8.48,;23.84,-7.71,;23.87,-6.17,;22.57,-5.38,;25.2,-5.41,;21.16,-10.77,;19.83,-10,;19.84,-8.46,;18.49,-10.76,;17.15,-9.98,;15.81,-10.74,;15.8,-12.28,;14.5,-9.95,;14.51,-8.41,;15.85,-7.66,;15.86,-6.12,;17.19,-5.35,;17.2,-3.81,;15.89,-3,;18.56,-3.03,;13.14,-10.68,;11.8,-9.92,;11.82,-8.38,;10.46,-10.68,;10.44,-12.22,;9.13,-9.89,;7.79,-10.64,;6.46,-9.85,;7.76,-12.18,;18.47,-12.3,;17.13,-13.06,;19.8,-13.08,;26.46,-12.38,;27.8,-13.16,;25.11,-13.14,;35.83,-10.15,;35.85,-8.61,;37.17,-10.9,;38.51,-10.15,;38.53,-8.61,;39.86,-7.84,;39.89,-6.3,;41.22,-5.54,;41.23,-4,;39.93,-3.21,;42.6,-3.24,;39.84,-10.92,;39.83,-12.46,;41.18,-10.17,;42.5,-10.97,;42.49,-12.51,;43.82,-13.28,;43.8,-14.82,;45.12,-15.6,;45.13,-17.13,;43.84,-10.2,;43.85,-8.66,;45.18,-10.97,;46.53,-10.22,;46.53,-8.68,;47.89,-7.92,;47.84,-11.01,;47.83,-12.55,;49.18,-10.24,;50.51,-11.03,;51.85,-10.27,;53.18,-11.06,;54.52,-10.3,;55.84,-11.08,;57.19,-10.32,;57.21,-8.78,;58.53,-11.09,;59.88,-10.34,;61.21,-11.14,;62.55,-10.38,;63.87,-11.16,;65.21,-10.41,;66.55,-11.18,;66.55,-12.73,;67.88,-10.4,;67.88,-8.86,;66.57,-8.1,;66.57,-6.54,;65.26,-5.78,;65.26,-4.22,;63.92,-3.46,;63.91,-1.92,;65.27,-1.13,;62.59,-1.15,;61.25,-1.88,;59.93,-1.1,;59.96,.44,;61.3,1.21,;62.62,.4,;64.17,1.67,;63.67,3.12,;62.15,3.41,;61.65,4.86,;62.66,6.02,;62.15,7.46,;64.17,5.73,;64.67,4.29,;66.19,3.99,;66.7,2.54,;68.18,2.27,;68.7,.83,;70.22,.55,;67.69,-.34,;66.18,-.07,;65.69,1.39,;61.25,-3.42,;59.92,-4.21,;62.58,-4.19,;69.24,-8.08,;69.24,-6.58,;70.59,-8.86,)|
Structure
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