| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase A |
|---|
| Ligand | BDBM50318606 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_633156 (CHEMBL1119040) |
|---|
| IC50 | 55±n/a nM |
|---|
| Citation |  Bavetsias, V; Large, JM; Sun, C; Bouloc, N; Kosmopoulou, M; Matteucci, M; Wilsher, NE; Martins, V; Reynisson, J; Atrash, B; Faisal, A; Urban, F; Valenti, M; de Haven Brandon, A; Box, G; Raynaud, FI; Workman, P; Eccles, SA; Bayliss, R; Blagg, J; Linardopoulos, S; McDonald, E Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem53:5213-28 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase A |
|---|
| Name: | Aurora kinase A |
|---|
| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45830.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14965 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
|---|
| BDBM50318606 |
|---|
| n/a |
|---|
| Name | BDBM50318606 |
|---|
| Synonyms: | (4-(6-Chloro-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3Himidazo[4,5-b]pyridin-2-yl)phenyl)methanamine | CHEMBL1085131 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24ClN7O |
|---|
| Mol. Mass. | 437.925 |
|---|
| SMILES | Cc1cc(CN2CCN(CC2)c2c(Cl)cnc3nc([nH]c23)-c2ccc(CN)cc2)no1 |
|---|
| Structure | 
|
|---|
Search and Browse
