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TargetLysosomal acid lipase/cholesteryl ester hydrolase
LigandBDBM50318690
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633497 (CHEMBL1119694)
IC50 68±n/a nM
Citation Rosenbaum, AICosner, CCMariani, CJMaxfield, FRWiest, OHelquist, P Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem53:5281-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysosomal acid lipase/cholesteryl ester hydrolase
Name:Lysosomal acid lipase/cholesteryl ester hydrolase
Synonyms:LICH_HUMAN | LIPA
Type:PROTEIN
Mol. Mass.:45422.01
Organism:Homo sapiens (Human)
Description:ChEMBL_633497
Residue:399
Sequence:
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI
LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS
RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG
FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL
KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV
KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI
TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
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  Blast E-value cutoff:
BDBM50318690
n/a
NameBDBM50318690
Synonyms:4-Piperidinyl-1,2,5-thiadiazolyl-3-morpholine carboxylate | CHEMBL1085463
TypeSmall organic molecule
Emp. Form.C12H18N4O3S
Mol. Mass.298.361
SMILESO=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
Structure
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