| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Ligand | BDBM50318692 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_633497 (CHEMBL1119694) |
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| IC50 | 473±n/a nM |
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| Citation |  Rosenbaum, AI; Cosner, CC; Mariani, CJ; Maxfield, FR; Wiest, O; Helquist, P Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem53:5281-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Name: | Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Synonyms: | LICH_HUMAN | LIPA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45422.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_633497 |
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| Residue: | 399 |
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| Sequence: | MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI
LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS
RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG
FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL
KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV
KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI
TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
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| BDBM50318692 |
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| n/a |
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| Name | BDBM50318692 |
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| Synonyms: | 4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate | CHEMBL1085856 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N4O3S |
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| Mol. Mass. | 284.335 |
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| SMILES | O=C(Oc1nsnc1N1CCCC1)N1CCOCC1 |
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| Structure | 
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