| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50318700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_633510 (CHEMBL1119824) |
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| Ki | 3.2±n/a nM |
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| Citation |  Cox, CD; Breslin, MJ; Whitman, DB; Schreier, JD; McGaughey, GB; Bogusky, MJ; Roecker, AJ; Mercer, SP; Bednar, RA; Lemaire, W; Bruno, JG; Reiss, DR; Harrell, CM; Murphy, KL; Garson, SL; Doran, SM; Prueksaritanont, T; Anderson, WB; Tang, C; Roller, S; Cabalu, TD; Cui, D; Hartman, GD; Young, SD; Koblan, KS; Winrow, CJ; Renger, JJ; Coleman, PJ Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. J Med Chem53:5320-32 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50318700 |
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| n/a |
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| Name | BDBM50318700 |
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| Synonyms: | 2-{(5R)-5-Methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}1,3-benzoxazole | CHEMBL1083658 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N6O2 |
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| Mol. Mass. | 416.4757 |
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| SMILES | C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2ccccc2o1 |r| |
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| Structure | 
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