Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50319823 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634878 (CHEMBL1120510) |
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Ki | 30±n/a nM |
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Citation | Fray, MJ; Fish, PV; Allan, GA; Bish, G; Clarke, N; Eccles, R; Harrison, AC; Le Net, JL; Phillips, SC; Regan, N; Sobry, C; Stobie, A; Wakenhut, F; Westbrook, D; Westbrook, SL; Whitlock, GA Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity. Bioorg Med Chem Lett20:3788-92 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50319823 |
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n/a |
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Name | BDBM50319823 |
Synonyms: | 1-(1-(3-fluorophenyl)-2-(2-methoxyphenyl)ethyl)piperazine | CHEMBL1085321 |
Type | Small organic molecule |
Emp. Form. | C19H23FN2O |
Mol. Mass. | 314.3971 |
SMILES | COc1ccccc1CC(N1CCNCC1)c1cccc(F)c1 |
Structure |
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