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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1
LigandBDBM50321447
Substrate/Competitorn/a
Meas. Tech.ChEMBL_640754 (CHEMBL1175695)
IC50 58800±n/a nM
Citation Caridha, DKathcart, AKJirage, DWaters, NC Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases. Bioorg Med Chem Lett20:3863-7 (2010) [PubMed]  Article
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Name:Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Synonyms:CDK6/cyclin D1 | Cyclin-dependent kinase 6/G1/S-specific cyclin D1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1935149
Components:This complex has 2 components.
Component 1
Name:G1/S-specific cyclin-D1
Synonyms:B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene
Type:Enzyme Subunit
Mol. Mass.:33717.70
Organism:Homo sapiens (Human)
Description:n/a
Residue:295
Sequence:
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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Component 2
Name:Cyclin-dependent kinase 6
Synonyms:CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:Enzyme Subunit
Mol. Mass.:36937.42
Organism:Homo sapiens (Human)
Description:Q00534
Residue:326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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BDBM50321447
n/a
NameBDBM50321447
Synonyms:2,4,5-trichloro-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide | CHEMBL1171969
TypeSmall organic molecule
Emp. Form.C13H7Cl3F3NO2S
Mol. Mass.404.619
SMILESFC(F)(F)c1cccc(NS(=O)(=O)c2cc(Cl)c(Cl)cc2Cl)c1
Structure
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