| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50322341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_642739 (CHEMBL1177219) |
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| Ki | 870±n/a nM |
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| Citation |  Bova, F; Ettari, R; Micale, N; Carnovale, C; Schirmeister, T; Gelhaus, C; Leippe, M; Grasso, S; Zappalà, M Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem18:4928-38 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50322341 |
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| n/a |
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| Name | BDBM50322341 |
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| Synonyms: | CHEMBL1171803 | Methyl4-(2-((R)-3-((4-chloro-2-(trifluoromethyl)phenylcarbamoyloxy)methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)-6-methylhept-2-enoate |
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| Type | Small organic molecule |
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| Emp. Form. | C35H34ClF3N4O6 |
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| Mol. Mass. | 699.116 |
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| SMILES | COC(=O)\C=C\[C@H](CC(C)C)NC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1 |r,c:23| |
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| Structure | 
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