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Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
LigandBDBM50322358
Substrate/Competitorn/a
Meas. Tech.ChEMBL_642746 (CHEMBL1177226)
IC50 15.1±n/a nM
Citation Aboraia, ASYee, SWGomaa, MSShah, NRobotham, ACMakowski, BProsser, DBrancale, AJones, GSimons, C Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides. Bioorg Med Chem18:4939-46 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Name:1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Synonyms:1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1
Type:Protein
Mol. Mass.:58889.66
Organism:Homo sapiens (Human)
Description:Q07973
Residue:514
Sequence:
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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  Blast E-value cutoff:
BDBM50322358
n/a
NameBDBM50322358
Synonyms:4'-Chloro-biphenyl-4-carboxylic acid((R)-2-imidazol-1-yl-2-phenyl-ethyl)-amide | CHEMBL1170908
TypeSmall organic molecule
Emp. Form.C24H20ClN3O
Mol. Mass.401.888
SMILESClc1ccc(cc1)-c1ccc(cc1)C(=O)NC[C@@H](c1ccccc1)n1ccnc1 |r|
Structure
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