| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50322698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_642191 (CHEMBL1176742) |
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| Ki | 1.58±n/a nM |
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| Citation |  Micheli, F; Cavanni, P; Andreotti, D; Arban, R; Benedetti, R; Bertani, B; Bettati, M; Bettelini, L; Bonanomi, G; Braggio, S; Carletti, R; Checchia, A; Corsi, M; Fazzolari, E; Fontana, S; Marchioro, C; Merlo-Pich, E; Negri, M; Oliosi, B; Ratti, E; Read, KD; Roscic, M; Sartori, I; Spada, S; Tedesco, G; Tarsi, L; Terreni, S; Visentini, F; Zocchi, A; Zonzini, L; Di Fabio, R 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem53:4989-5001 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | Htt | SC6A4_MOUSE | Serotonin transporter | Sert | Slc6a4 | Sodium-dependent serotonin transporter | Solute carrier family 6 member 4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 70044.92 |
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| Organism: | MOUSE |
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| Description: | 5-HT Transporter SLC6A4 MOUSE::Q60857 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAP
HSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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| BDBM50322698 |
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| n/a |
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| Name | BDBM50322698 |
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| Synonyms: | rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptane |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17Cl2NO |
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| Mol. Mass. | 286.197 |
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| SMILES | COC[C@]12C[C@]1(CCNC2)c1ccc(Cl)c(Cl)c1 |r| |
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| Structure | 
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