Reaction Details |
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Target | Cytochrome P450 11B1, mitochondrial |
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Ligand | BDBM31768 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_642392 (CHEMBL1177585) |
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IC50 | 127±n/a nM |
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Citation | Hu, Q; Yin, L; Jagusch, C; Hille, UE; Hartmann, RW Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. J Med Chem53:5049-53 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B1, mitochondrial |
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Name: | Cytochrome P450 11B1, mitochondrial |
Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
Type: | Enzyme |
Mol. Mass.: | 57591.44 |
Organism: | Homo sapiens (Human) |
Description: | P15538 |
Residue: | 503 |
Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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BDBM31768 |
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n/a |
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Name | BDBM31768 |
Synonyms: | CHEMBL295698 | Ketoconazole | Nizoral | Panfungol |
Type | Small organic molecule |
Emp. Form. | C26H28Cl2N4O4 |
Mol. Mass. | 531.431 |
SMILES | CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
Structure |
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