| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 15 |
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| Ligand | BDBM50108563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_643935 (CHEMBL1211834) |
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| Ki | 652±n/a nM |
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| Citation |  Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg Med Chem Lett20:4376-81 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 15 |
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| Name: | Carbonic anhydrase 15 |
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| Synonyms: | CAH15_MOUSE | Ca15 | Car15 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35484.02 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_651955 |
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| Residue: | 324 |
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| Sequence: | MWALDFLLSFLLIQLAAQVDSSGTWCYDSQDPKCGPAHWKELAPACGGPTQSPINIDLRL
VQRDYTLKPFIFQGYDSAPQDPWVLENDGHTVLLRVNSCQQNCPAIRGAGLPSPEYRLLQ
LHFHWGSPGHQGSEHSLDEKHGSMEMHMVHMNTKYQSMEDARSQPDGFAILAVLLVEEDR
DNTNFSAIVSGLKNLSSPGVAVNLTSTFALASLLPSALRLLRYYRYSGSLTTPGCEPAVL
WTVFENTVPIGHAQVVQFQAVLQTGPPGLHPRPLTSNFRPQQPLGGRRISASPEASVRSS
VSTLPCLHLALVGLGVGLRLWQGP
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| BDBM50108563 |
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| n/a |
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| Name | BDBM50108563 |
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| Synonyms: | Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | CHEMBL108971 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18N4O3S2 |
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| Mol. Mass. | 342.437 |
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| SMILES | NS(=O)(=O)c1nnc(NC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)s1 |TLB:18:17:20:12.13.14,18:13:20:19.17.16| |
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| Structure | 
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