Ki Summary

Reaction Details

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Target

Segment polarity protein dishevelled homolog DVL-2

Ligand

BDBM50378802

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_651099 (CHEMBL1227540)

1200±n/a nM

Citation

Zhang, Y; Appleton, BA; Wiesmann, C; Lau, T; Costa, M; Hannoush, RN; Sidhu, SS Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol5:217-9 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Segment polarity protein dishevelled homolog DVL-2

Name:

Segment polarity protein dishevelled homolog DVL-2

Synonyms:

DSH homolog 2 | DVL2 | DVL2_HUMAN | Dishevelled-2

Type:

PROTEIN

Mol. Mass.:

78940.00

Organism:

Homo sapiens (Human)

Description:

ChEMBL_651099

Residue:

736

Sequence:

MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSM
DQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPL
PPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTG
GPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRR
KQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIM
KGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQ
AYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVH
TDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYAS
GLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLP
GATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGG
AGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRA
HPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQS
FHMAMGNPSEFFVDVM

BDBM50378802

n/a

Name

BDBM50378802

Synonyms:

CHEMBL1222068

Type

Small organic molecule

Emp. Form.

C53H67N11O14

Mol. Mass.

1082.1644

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|

Structure