| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM50324735 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_651342 (CHEMBL1227162) |
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| IC50 | 13000±n/a nM |
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| Citation |  Geldenhuys, WJ; Darvesh, AS; Funk, MO; Van der Schyf, CJ; Carroll, RT Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening. Bioorg Med Chem Lett20:5295-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) |
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| Type: | Protein |
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| Mol. Mass.: | 58768.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27338 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
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| BDBM50324735 |
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| n/a |
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| Name | BDBM50324735 |
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| Synonyms: | (5E)-5-(QUINOXALIN-6-YLMETHYLENE)-1,3-THIAZOLIDINE-2,4-DIONE | 5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione | AS-605240 | AS605240 | CHEMBL568150 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H7N3O2S |
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| Mol. Mass. | 257.268 |
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| SMILES | OC1=NC(=O)C(S1)=Cc1ccc2nccnc2c1 |w:7.8,t:1| |
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| Structure | 
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