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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase ABL1 | ||
| Ligand | BDBM50378811 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_652025 (CHEMBL1227835) | ||
| Ki | 20±n/a nM | ||
| Citation |  Kraus, GA; Gupta, V; Mokhtarian, M; Mehanovic, S; Nilsen-Hamilton, M New effective inhibitors of the Abelson kinase. Bioorg Med Chem18:6316-21 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase ABL1 | |||
| Name: | Tyrosine-protein kinase ABL1 | ||
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122897.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00519 | ||
| Residue: | 1130 | ||
| Sequence: |
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| BDBM50378811 | |||
| n/a | |||
| Name | BDBM50378811 | ||
| Synonyms: | CHEMBL1223483 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H30Cl2N6O3S | ||
| Mol. Mass. | 637.579 | ||
| SMILES | Cn1c2nc(NCc3cccc(c3)C(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |r,wU:19.19,27.27,22.23,(33.85,-43.02,;33.87,-41.48,;32.57,-40.68,;31.23,-41.44,;29.91,-40.64,;28.59,-41.42,;27.24,-40.66,;25.92,-41.44,;25.93,-42.99,;24.61,-43.76,;23.26,-43.01,;23.25,-41.47,;24.58,-40.69,;21.9,-40.71,;21.88,-39.18,;20.59,-41.5,;20.6,-43.04,;19.28,-43.82,;19.25,-45.36,;18.02,-46.28,;16.55,-45.82,;15.66,-47.08,;16.58,-48.32,;16.6,-49.86,;18.07,-50.31,;18.56,-51.77,;18.96,-49.05,;18.04,-47.82,;29.94,-39.11,;31.27,-38.35,;32.6,-39.14,;33.95,-38.4,;35.27,-39.2,;36.62,-38.46,;36.65,-36.92,;35.33,-36.13,;37.99,-36.18,;39.31,-36.97,;39.29,-38.52,;37.92,-39.26,;37.9,-40.79,;35.24,-40.74,;36.55,-41.54,)| | ||
| Structure | 
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