Reaction Details | |||
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Target | Tyrosine-protein kinase ABL1 | ||
Ligand | BDBM50303233 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_652025 (CHEMBL1227835) | ||
Ki | 0.02±n/a nM | ||
Citation | Kraus, GA; Gupta, V; Mokhtarian, M; Mehanovic, S; Nilsen-Hamilton, M New effective inhibitors of the Abelson kinase. Bioorg Med Chem18:6316-21 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase ABL1 | |||
Name: | Tyrosine-protein kinase ABL1 | ||
Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
Type: | Enzyme | ||
Mol. Mass.: | 122897.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P00519 | ||
Residue: | 1130 | ||
Sequence: |
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BDBM50303233 | |||
n/a | |||
Name | BDBM50303233 | ||
Synonyms: | 2-(3-aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | CHEMBL577269 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H15Cl2N5O | ||
Mol. Mass. | 412.272 | ||
SMILES | Cn1c2nc(Nc3cccc(N)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(1.69,-30.93,;1.69,-29.39,;.36,-28.62,;-.97,-29.39,;-2.3,-28.62,;-3.63,-29.39,;-4.96,-28.63,;-4.97,-27.08,;-6.3,-26.31,;-7.63,-27.08,;-7.63,-28.63,;-8.97,-29.4,;-6.3,-29.4,;-2.31,-27.09,;-.98,-26.31,;.36,-27.08,;1.69,-26.31,;3.02,-27.07,;4.34,-26.3,;4.33,-24.76,;3,-24,;5.66,-23.99,;7,-24.75,;7.01,-26.29,;5.68,-27.07,;5.68,-28.61,;3.03,-28.62,;4.36,-29.39,)| | ||
Structure |