Reaction Details |
| Report a problem with these data |
Target | Translocator protein |
---|
Ligand | BDBM50327235 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_664273 (CHEMBL1259308) |
---|
Ki | 4.8±n/a nM |
---|
Citation | Reynolds, A; Hanani, R; Hibbs, D; Damont, A; Da Pozzo, E; Selleri, S; Dollé, F; Martini, C; Kassiou, M Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorg Med Chem Lett20:5799-802 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Translocator protein |
---|
Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
|
|
|
BDBM50327235 |
---|
n/a |
---|
Name | BDBM50327235 |
Synonyms: | 2-[5,7-Dimethyl-2-(4-(prop-2-yn-1-yloxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide | CHEMBL1258843 |
Type | Small organic molecule |
Emp. Form. | C23H26N4O2 |
Mol. Mass. | 390.4781 |
SMILES | CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(OCC#C)cc1 |
Structure |
|