| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
|---|
| Ligand | BDBM50330441 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_684876 (CHEMBL1286200) |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Asagarasu, A; Matsui, T; Hayashi, H; Tamaoki, S; Yamauchi, Y; Minato, K; Sato, M Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome. J Med Chem53:7549-63 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 4 |
|---|
| Name: | 5-hydroxytryptamine receptor 4 |
|---|
| Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43735.29 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
|
|
|
|---|
| BDBM50330441 |
|---|
| n/a |
|---|
| Name | BDBM50330441 |
|---|
| Synonyms: | 3-amino-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)butyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one | CHEMBL1278088 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32N6O |
|---|
| Mol. Mass. | 432.5612 |
|---|
| SMILES | Nn1c(CCCCN2CCN(CC2)c2ccc3ccccc3n2)nc2CCCCc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
