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TargetSerine/threonine-protein kinase Nek2
LigandBDBM50335188
Substrate/Competitorn/a
Meas. Tech.ChEMBL_701550 (CHEMBL1656189)
IC50>100±n/a nM
Citation Kerekes, ADEsposite, SJTagat, JRXiao, YTerracina, GA Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure. J Med Chem54:201-10 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Nek2
Name:Serine/threonine-protein kinase Nek2
Synonyms:NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:Enzyme
Mol. Mass.:51776.96
Organism:Homo sapiens (Human)
Description:P51955
Residue:445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50335188
n/a
NameBDBM50335188
Synonyms:CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride
TypeSmall organic molecule
Emp. Form.C18H18F2N8S
Mol. Mass.416.451
SMILESCc1cn2c(cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1)-c1cn[nH]c1
Structure
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