Reaction Details |
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Target | Calcium/calmodulin-dependent protein kinase type IV |
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Ligand | BDBM50329198 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_701560 (CHEMBL1656199) |
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IC50 | >100±n/a nM |
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Citation | Kerekes, AD; Esposite, SJ; Tagat, JR; Xiao, Y; Terracina, GA Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure. J Med Chem54:201-10 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calcium/calmodulin-dependent protein kinase type IV |
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Name: | Calcium/calmodulin-dependent protein kinase type IV |
Synonyms: | CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 51919.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1459854 |
Residue: | 473 |
Sequence: | MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
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BDBM50329198 |
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n/a |
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Name | BDBM50329198 |
Synonyms: | 2-(ethyl((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol | 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol | CHEMBL1232515 | CHEMBL1650533 |
Type | Small organic molecule |
Emp. Form. | C20H26N8OS |
Mol. Mass. | 426.538 |
SMILES | CCN(Cc1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1)C(C)(C)CO |
Structure |
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