| Reaction Details |
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 | Report a problem with these data |
| Target | Testis-specific serine/threonine-protein kinase 2 |
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| Ligand | BDBM50329198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701545 (CHEMBL1656184) |
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| IC50 | >100±n/a nM |
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| Citation |  Kerekes, AD; Esposite, SJ; Tagat, JR; Xiao, Y; Terracina, GA Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure. J Med Chem54:201-10 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Testis-specific serine/threonine-protein kinase 2 |
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| Name: | Testis-specific serine/threonine-protein kinase 2 |
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| Synonyms: | DGSG | SPOGA2 | STK22B | TSSK2 | TSSK2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40954.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1459845 |
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| Residue: | 358 |
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| Sequence: | MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE
MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL
SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA
YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN
LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD
TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
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| BDBM50329198 |
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| n/a |
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| Name | BDBM50329198 |
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| Synonyms: | 2-(ethyl((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol | 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol | CHEMBL1232515 | CHEMBL1650533 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N8OS |
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| Mol. Mass. | 426.538 |
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| SMILES | CCN(Cc1cc(Nc2nc(C)cn3c(cnc23)-c2cn[nH]c2)sn1)C(C)(C)CO |
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| Structure | 
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