| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 5A |
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| Ligand | BDBM50335201 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701827 (CHEMBL1656964) |
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| IC50 | 41±n/a nM |
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| Citation |  Ioannidis, S; Lamb, ML; Wang, T; Almeida, L; Block, MH; Davies, AM; Peng, B; Su, M; Zhang, HJ; Hoffmann, E; Rivard, C; Green, I; Howard, T; Pollard, H; Read, J; Alimzhanov, M; Bebernitz, G; Bell, K; Ye, M; Huszar, D; Zinda, M Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J Med Chem54:262-76 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 5A |
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| Name: | Signal transducer and activator of transcription 5A |
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| Synonyms: | STA5A_HUMAN | STAT5 | STAT5A | Signal transducer and activator of transcription 5A | Transcription factor STAT5a (STAT5a) |
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| Type: | Protein |
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| Mol. Mass.: | 90643.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 794 |
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| Sequence: | MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
PPAGLFTSARGSLS
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| BDBM50335201 |
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| n/a |
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| Name | BDBM50335201 |
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| Synonyms: | 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | CHEMBL1231124 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14ClFN8 |
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| Mol. Mass. | 348.766 |
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| SMILES | C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| |
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| Structure | 
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