| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
|---|
| Ligand | BDBM50335201 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_701695 (CHEMBL1656587) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Ioannidis, S; Lamb, ML; Wang, T; Almeida, L; Block, MH; Davies, AM; Peng, B; Su, M; Zhang, HJ; Hoffmann, E; Rivard, C; Green, I; Howard, T; Pollard, H; Read, J; Alimzhanov, M; Bebernitz, G; Bell, K; Ye, M; Huszar, D; Zinda, M Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J Med Chem54:262-76 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 3 |
|---|
| Name: | Signal transducer and activator of transcription 3 |
|---|
| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88064.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P40763 |
|---|
| Residue: | 770 |
|---|
| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
|
|
|
|---|
| BDBM50335201 |
|---|
| n/a |
|---|
| Name | BDBM50335201 |
|---|
| Synonyms: | 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | CHEMBL1231124 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14ClFN8 |
|---|
| Mol. Mass. | 348.766 |
|---|
| SMILES | C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
