Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM50335225 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_701872 (CHEMBL1657164) |
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Ki | 230±n/a nM |
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Citation | Juli, C; Sippel, M; Jäger, J; Thiele, A; Weiwad, M; Schweimer, K; Rösch, P; Steinert, M; Sotriffer, CA; Holzgrabe, U Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein. J Med Chem54:277-83 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM50335225 |
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n/a |
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Name | BDBM50335225 |
Synonyms: | (S)-1-Phenylmethanesulfonyl-piperidine-2-carboxylic acid 3-(3,4,5-trimethoxy-phenyl)-propyl ester | (S)-3-(3,4,5-Trimethoxyphenyl)propyl 1-(benzylsulfonyl)-piperidine-2-carboxylate | CHEMBL109278 |
Type | Small organic molecule |
Emp. Form. | C25H33NO7S |
Mol. Mass. | 491.597 |
SMILES | COc1cc(CCCOC(=O)[C@@H]2CCCCN2S(=O)(=O)Cc2ccccc2)cc(OC)c1OC |
Structure |
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