| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50335258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_702766 (CHEMBL1655209) |
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| Ki | 19.5±n/a nM |
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| Citation |  Pike, VW; Taliani, S; Lohith, TG; Owen, DR; Pugliesi, I; Da Pozzo, E; Hong, J; Zoghbi, SS; Gunn, RN; Parker, CA; Rabiner, EA; Fujita, M; Innis, RB; Martini, C; Da Settimo, F Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J Med Chem54:366-73 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50335258 |
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| n/a |
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| Name | BDBM50335258 |
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| Synonyms: | 2-(1-methyl-2-phenyl-1H-indol-3-yl)-2-oxo-N,N-dipropylacetamide | CHEMBL1651224 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N2O2 |
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| Mol. Mass. | 362.4647 |
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| SMILES | CCCN(CCC)C(=O)C(=O)c1c(-c2ccccc2)n(C)c2ccccc12 |
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| Structure | 
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